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Signaling via pancreatic -cells underlies the insulinotropic effects of GLP-1 RAs, while activation of enteric GLP-1Rs delays gastric emptying, effectively blunting postprandial glucose spikes and prolonging satiety (Kreymann et al., 1987

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* Correspondence: Haoyu Wang, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

If a small crystal of sodium acetate trihydrate is added to the liquid, however, the contents of the flask solidify within seconds